Web Desk. Scientists have for the first time discovered an antibody that helps prevent the virus that causes dengue fever from spreading in the body. A joint study by the University of California and the University of Michigan in the United States discovered an antibody that blocks the spread of the mosquito-borne dengue virus.
It is estimated that 5 to 100 million people worldwide are infected with dengue each year, the symptoms of which include fever, vomiting, and muscle aches, while the severity of the disease increases the risk of death.
There are currently no effective treatments or vaccines for the dengue virus, as there are four types of the virus, so the development of antibodies against one type can make people weaker than the other, leading to the discovery of more effective treatments. It’s difficult.
The dengue virus uses a specific protein, called NS1, which lures the protective cells around the organs. This weakens the protective barrier and allows the virus to infect cells, which can also affect blood vessels.
During the study, experts tested an antibody 2B7 that was able to block the NS1 protein, preventing the virus from attaching to cells and slowing its spread. According to researchers, because it attacks the protein directly instead of the antibody virus, it can be effective against all four types of dengue virus.
Researchers using X-ray diffraction techniques to test its effectiveness proved that this antibody can provide protection against the virus. The researchers used this antibody in live mice to prevent the spread of the dengue virus.
The results of the study, published in the medical journal Science, suggest that the antibody may also be helpful against other viruses such as dengue, Zika, and West Nile. Researchers say that mosquito-borne viruses infect millions of people each year and cause millions of deaths from the disease.
He added that the protein structure of the virus plays a central role in the development of drugs and vaccines for various diseases and these new findings could also be the key to the development of effective treatment against dengue.